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Closed-Loop Neuromodulation Clinical Trials

10 actively recruiting studies

Feasibility and Safety of a Combined Augmented Reality and Functional Electrical Stimulation System
NCT07299734 · Phase: EARLY_PHASE1 · Started 2026-01

Cervical spinal cord injury (cSCI) can result in substantial loss of upper-limb function, with associated socio-economic impact on affected individuals and the healthcare system. Evidence suggests tha...

Toronto, Ontario, Canada
Recruiting
Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease
NCT05904132 · Phase: NA · Started 2025-01-31

The project is a placebo-controlled study that aims to use closed-loop transcranial alternating current stimulation (tACS) to study patients with symptoms of mild cognitive impairment which is likely ...

Charlestown, Massachusetts, United States
Recruiting
Reduction of Auditory-Verbal Hallucinations in Schizophrenia Through Cortical Neuromodulation
NCT06361160 · Phase: NA · Started 2024-05-21

Approximately 1% of the general population will be affected by schizophrenia over the course of their lives, with life expectancy being reduced by 20 years on average and quality of life being severel...

Paris, France
Recruiting
Evaluation of Medication Tapering on the Sensitivity of the Spinal Cord Using Closed-Loop Spinal Cord Stimulation (Pilot
NCT07502612 · Phase: Not specified · Started 2022-06-08

This pilot study investigates the effects of reducing pain medication including opioids and anticonvulsants, on spinal cord sensitivity during closed-loop spinal cord stimulation (SCS). Patients with ...

Wilrijk, Belgium
Recruiting
Study to Compare the Clinical Effectiveness and Cost Utility of an All-in-one Procedure With an At-home Screening Trial
NCT06996574 · Phase: NA · Started 2025-06-06

In 2019, the Dutch Healthcare Institute published a consensus report outlining when spinal cord stimulation (SCS) for chronic pain qualifies for reimbursement under Dutch health insurance. It mandates...

Amsterdam, Netherlands
Recruiting
Deep Brain Stimulation for Psychosis
NCT06257056 · Phase: NA · Started 2024-04-03

There are three hypotheses proposed for this study: 1) Participants will report no unanticipated serious adverse events during the eight months of treatment. 2) Investigators will successfully model p...

Dallas, Texas, United States
Recruiting
Neurophysiological Effects of Medication Tapering During Treatment With Spinal Cord Stimulation
NCT07413731 · Phase: Not specified · Started 2025-02-03

This study is being conducted in patients who will receive a spinal cord stimulator. This device helps manage chronic neuropathic pain in the trunk and/or limbs. The patients will receive a spinal cor...

Wilrijk, Belgium
Recruiting
MRI Guided Closed-loop TMS-EEG
NCT06050603 · Phase: NA · Started 2023-09-07

The goal of this interventional study is to develop an individualized approach using transcranial magnetic stimulation (TMS) in a high-precision manner. This approach will use TMS to modulate brain ac...

Toronto, Ontario, Canada
Recruiting
Closed-loop cTBS for the Core Clinical Features of Methamphetamine Use Disorder
NCT06457243 · Phase: NA · Started 2024-08

Using specific EEG biomarkers in methamphetamine-dependent individuals, this study systematically probes closed-loop continuous Theta-burst Stimulation (cTBS) based on brain states, assessing dosage, ...

Shanghai, Shanghai Municipality, China
Recruiting
Transcranial Magnetic Stimulation Synchronized with Motor Task Training for Post-Stroke Rehabilitation
NCT06849505 · Phase: NA · Started 2024-07-02

The goal of this clinical trials is to investigate the effectiveness of individualized online repetitive transcranial magnetic stimulation (rTMS) in enhancing upper limb motor rehabilitation during th...

Shanghai, Shanghai Municipality, China
Recruiting